LC/MS/MS 初級代謝物分析方法包

LC/MS/MS Method Package for Primary Metabolites

用於初級代謝物分析的 LC/MS/MS 方法包 Ver.3

200 種化合物的 Ready-to-use 方法

此方法包能夠高效率且同步的對大量化合物進行分析。提供最佳化的 LC 分離條件和 MS 參數大大減少了在方法開發上花費的時間和精力。

選擇最佳化分析條件

依照您的分析目標和擁有的配備來選擇合適的分析方法。離子對試劑法 (112 種化合物) 適用於醣磷酸鹽的分析，而非離子對試劑法 (141 種化合物) 不需要使用離子對試劑，對於高附加價值物質的研究很有助益，此版本已擴充包括參與 mevalonate 和 shikimic acid 途徑的化合物。

Overlaid MRM chromatograms for simultaneous analysis of a mixture of 141 standards with the non-ion-pair reagent method

使用非離子對試劑方法同時分析 141 種標準混合物的 MRM 層析圖。

代謝變化的視覺化呈現

透過隨附的多體學數據分析軟體，繪製定量數據柱狀圖在代謝路徑圖上。

Visualization of simultaneous analysis results from the PFPP column method, created with the Multi-omics Data Analysis Package

PFPP 管柱方法同步分析的數據結果。

與 Nexera™ 系列和 LCMS-8060NX 相容

所有方法均與 Nexera 系列和 LCMS-8045/8050/8060 (NX) 相容，涵蓋了廣泛的分析需求。

從前處理到分析的整體解決方案

此方法包包括生物組織萃取物的製備，使用經過驗證的前處理技術進行穩定分析，並減少方法開發中涉及的勞力和費用。

http://www.garuda-alliance.org/

化合物目錄

離子對試劑方法的化合物清單
Glycolytic system	Co-enzyme	Nucleotides
2,3-Bisphosphoglyceric acid 3-Phosphoglyceric acid (2-Phosphoglyceric acid) Dihydroxyacetone phosphate Fructose 1,6-bisphosphate Glucose 1-phosphate Glucose 6-phosphate Glycerol 3-phosphate Phosphoenolpyruvic acid Pyruvic acid	3-Hydroxybutyryl coenzyme A Butyryl coenzyme A Coenzyme A Crotonyl coenzyme A FAD FMN Malonyl coenzyme A Methylmalonyl coenzyme A NAD NADH NADP NADPH Nicotinic acid Pyrroloquinoline quinone	Adenine Adenosine Adenosine 3',5'-cyclic monophosphate Adenosine diphosphate Adenosine monophosphate Adenosine triphosphate AICAR Cytidine Cytidine diphosphate Cytidine monophosphate Cytidine triphosphate Guanine Guanosine Guanosine 3',5'-cyclic monophosphate Guanosine diphosphate Guanosine monophosphate Guanosine triphosphate Inosine Inosine monophosphate Orotic acid Thymidine Thymidine diphosphate Thymidine monophosphate Thymidine triphosphate Thymine Uridine Uridine diphosphate Uridine monophosphate Uridine triphosphate Xanthosine monophosphate
Pentose-phosphate pathway
Fructose 6-phosphate Glyceraldehyde 3-phosphate 6-Phosphogluconic acid Erythrose 4-phosphate Ribose 1-phosphate Ribose 5-phosphate Ribulose 5-phosphate Sedoheptulose 7-phosphate
Sugar phosphate	Nonmevalonic acid pathway
Fructose 1-phosphate Mannose 6-phosphate Phosphoribosyl pyrophosphate Ribulose 1,5-bisphosphate	HMBPP IPP_DMAPP MEP
TCA cycle	Shikimic acid pathway
Acetyl coenzyme A 2-Ketoglutaric acid Succinyl coenzyme A	Shikimic acid Shikimic acid 3-phosphate
Amino acids	Organic acids	Nucleotide sugar
2-Aminobutyric acid 4-Aminobutyric acid Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine 4-Hydroxyproline Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine	2-Isopropylmalic acid 3-Hydroxyphenylacetic acid 4-Hydroxyphenyl pyruvic acid Citramalic acid Glyceric acid Glycerol 2-phosphate Glycerol 3-phosphate Glycolic acid Indole 3-acetic acid Pantothenic acid	ADP-glucose UDP-glucose
		Purine derivative
		Hypoxanthine Uric acid Xanthine
		Internal STDs
		2-Morpholinoethanesulfonic acid Methionine sulfone

PFPP 管柱方法的化合物清單
Glycolytic system	Organic acids	Co-enzyme
Lactic acid Pyruvic acid	2-Aminobutyric acid 4-Aminobenzoic acid 4-Aminobutyric acid Caffeic acid Cholic acid Creatine Ferulic acid Glycolic acid Glyoxylic acid Ophthalmic acid Orotic acid p-Coumaric acid Phenyllactic acid Phenylpyruvic acid Taurocholic acid Urocanic acid Vanillic acid	FAD FMN NAD Niacinamide Nicotinic acid
TCA cycle		Nonmevalonic acid pathway
2-Ketoglutaric acid Aconitic acid Citric acid Fumaric acid Isocitric acid Malic acid Succinic acid		DOXP MEP
Urea cycle	Catecholamine	Mevalonic acid pathway
Argininosuccinic acid Ornithine Citrulline	Dopamine Epinephrine Norepinephrine Serotonin	Mevalonic acid MVA-P
Amino acids	Vitamin B	Alkaloid
4-Hydroxyproline Alanine Anthranilic acid Arginine Asparagine Aspartic acid Asymmetric dimethylarginine Cystine Dimethylglycine Glutamic acid Glutamine Glycine Histidine Homocystine Isoleucine Leucine Lysine Methionine sulfoxide Phenylalanine Proline Serine Symmetric dimethylarginine Threonine Tryptophan Valine	Folic acid Pantothenic acid PLP	Higenamine Reticuline THP
	Nucleosides and Nucleotides	Others
	Adenine Adenosine Adenosine 3',5'-cyclic monophosphate Adenosine monophosphate Adenylsuccinic acid AICAR Cytidine Cytidine 3',5'-cyclic monophosphate Cytidine monophosphate Cytosine Guanine Guanosine Guanosine 3',5'-cyclic monophosphate Guanosine monophosphate Inosine Thymidine Thymidine monophosphate Thymine Tyrosine Uracil Uridine	4-Aminophenylalanine 4-Aminophenylpyruvic acid 4-Hydroxybenzoic acid Acetylcarnitine Acetylcholine Carnitine Carnosine Catechol Choline Citicoline Creatinine Cysteamine Dihydroxyphenylacetaldehyde Dihydroxyphenylacetic acid Dopa Ergothioneine Histamine Histidinol Hydroxytyrosol Indole Kynurenine Methyl-DOPA Protocatechuic acid Protocatechuic aldehyde Resveratrol Salicylic acid Sinapic acid Tyramine Vanillin
Methylation and Transsulfuration cycle	Purinederivative	Internal STDs
Cystathionine Cysteine Homocysteine Methionine 5-Glutamylcysteine Glutathione Oxidized glutathione S-Adenosylhomocysteine S-Adenosylmethionine	Allantoin Hypoxanthine Uric acid Xanthine	2-Morpholinoethanesulfonic acid Methionine sulfone
Shikimic acid pathway
3-Dehydroquinic acid 3-Dehydroshikimic acid Chorismic acid Shikimic acid Shikimic acid 3-phosphate

* 使用此方法包，您可以根據您的配備和分析目的選擇使用離子對試劑方法 (112 種化合物) 或 PFPP 管柱方法 (141 種化合物)。

注意事項

LabSolutions LCMS 版本需為 5.99 SP2 或更新。
本方法包僅供研究使用。

LabSolutions 和 Nexera 為 Shimadzu Corporation 的商標。
GARUDA 是系統生物學研究所的商標。

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