Nexera X4 - 規格

超高效液相層析儀

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Engineering Excellence for the Highest Performance

追求極致性能的創新設計

Nexera X4

 

兼顧儀器穩定性與卓越性能表現

Exhibiting Maximum Performance while Maintaining Instrument Robustness

 

Nexera X4 搭載獨家的 Nexflow 技術，無需改變管線內徑或長度，即可將管柱外擴散（Extra-column dispersion）現象降至最低。相較傳統設計不僅能降低管線阻塞的風險，更能有效抑制峰寬擴展（Peak broadening），實現優異的分離效能。

實現高速、高精度梯度的輸液裝置

Solvent Delivery Unit Achieves High-Speed High-Precision Gradients

 

LC-40B X4 為搭載獨立四驅動柱塞（Plunger）與壓力回饋機制的二元梯度泵（Binary gradient pump）。可大幅降低泵浦引起的壓力跳動，並顯著提升梯度反映。透過最先進的流體控制技術，實現了超高速梯度變化與基線的穩定。

擴展分析應用的移動相切換與除氣裝置

Mobile Phase Switching and Degassing Unit Broadens the Analysis Width

SSU-40 是一款用於二元幫浦的溶劑切換和線上除氣裝置，每個幫浦最多可切換 4 種溶液。自動移動相切換有助於提高方法篩選的效率。SSU-40 為專供二元泵使用之溶劑切換與線上脫氣單元，單一泵最多可支援 4 種液體的切換。透過自動切換移動相，協助提升探索分析條件的效率。

全新設計的低擴散且高靈敏度 PDA 偵測器

Newly Designed Low-Dispersion, High-Sensitivity PDA Detector

 

SPD-M40 X4 是一款採用毛細管流動池（Capillary cell），從而降低峰擴展（Peak dispersion）的PDA偵測器。它能有效減少源自溶劑的基線波動，並藉由寬廣的動態範圍（Dynamic range），實現從低濃度到高濃度廣泛樣品的分析。

  • 降低峰擴展與樣品殘留的高階自動進樣器
    High-End Autosampler Reduces Peak Broadening and Carryover

    SIL-40C X4 是一款搭載新設計高壓閥、低擴散進樣功能，以及高速樣品針內外清洗功能的高階自動進樣器。從要求高靈敏度的極低濃度，到需要強大清洗能力的高濃度樣品分析，皆能完美對應。

  • 兼具操作便利性與效能的管柱接頭
    Fitting Achieves Both Ease of Use and Low-Dispersion Performance

     

    新開發的 「Nexlock™ II」採用無套環（Ferrule-free）設計的端面密封結構，實現零死體積（Dead volume）的管線連接。此外，藉由獨家的接頭設計，即使在高耐壓條件下，仍可徒手鎖緊完成管柱連接。

 

Specifications

System Controller

    SCL-40 CBM-40 CBM-40lite
System Controller
 Monitor Touch panel LabSolutions™ Web monitor LabSolutions Web monitor LabSolutions Web monitor
Controllable unit Solvent delivery unit: Max. 4, Autosampler: 1, Column oven: Max. 4, Detector: Max. 2, etc.
Number of controllable units 8 (Using option: 12) 4 (excluding built-in solvent
delivery unit)
Event input/output Input: 1, Output: 2
Analog signal input Up to two channels (option) One channel (option) ー
Communication interface Ethernet
Reservoir tray Included as standard  
Dimensions and weight W260 × D500 × H140 mm, 6 kg W260 × D500 × H72 mm, 5 kg ー
Operating temperature range 4 to 35 °C
Power supply 100 to 240 V AC, 50 VA, 50/60 Hz Supplied from solvent delivery unit

Solvent Delivery Unit

  LC-40B X4
LC-40B X4 Pumping method Micro-volume double plunger pump
Allowable maximum pressure 130 MPa
Flow rate settings range 0.0001 to 2.0000 mL/min
Flow rate accuracy ±1 % (at 1 mL/min, 80 MPa, with water, stable within a temperature range of 20 to 30 °C)
Flow rate precision Retention time reproducibility:  ≤ 0.04 % RSD or ≤  0.003 min SD, whichever is greater
Gradient mode Two-solvent high-pressure gradient
Range of gradient mixing ratio 0 to 100 % (0.1 % step)
Gradient concentration precision ≤  0.1% RSD or ≤  0.008 min SD, whichever is greater (under specified conditions)
Wetted materials SUS316L, Co-Ni alloy, PEEK, ruby, sapphire, zirconia, Hastelloy C, polyethylene, fluoropolymer
Available pH range 1 to 14
Automatic rinsing kit Included as standard
Degassing unit 1 unit connectable
Dimensions and weight W260 × D500 × H210 mm (excluding protrusions), 24 kg
Operating temperature range 4 to 35 °C
Power supply 100 to 240 V AC, 50/60 Hz, 150 VA

Solvent Switching and Degassing Unit

  SSU-40
SSU-40

 

 Number of selectable
solvents		 Up to 4 solvents per pump (maximum 2 pumps)
Number of degassed
solvent lines		 5
Wetted materials Fluoropolymer, PEEK, PTFE, FEP, ETFE, perfluoroelastomer
Degassed flow line
capacity		 400 μL/1 line
Dimensions and weight W260 × D500 × H72 mm, 5 kg
Operating temperature
range		 4 to 35 °C
Power supply Supplied from the corresponding solvent delivery unit

Autosampler

  SIL-40C X4
SIL-40C X4

 

 Injection method Total-volume injection
Allowable maximum　pressure 130 MPa
Injection volume settings range 0.01 to 50 μL
Injection volume accuracy Within ±1% (5 μL injection, n = 20)
Linearity ≥ 0.9999
Injection cycle time ≤  6.7 seconds (under specified conditions)
Number of samples processed 288 (microtiter plate, 96 well × 3 plates)
1152 (microtiter plate, 384 well × 3 plates)
252 (1 mL sample vial, 84 × 3 plates)
162 (1.5 mL sample vial, 54 × 3 plates)
84 (4 mL sample vial, 28 × 3 plates)
36 (10 mL sample vial, 12 × 3 plates)
72 (1.5 mL micro tube, 24 × 3 plates)
Injection volume reproducibility RSD ≤  1.0% (0.5 to 0.9 μL)
RSD ≤  0.5% (1.0 to 1.9 μL)
RSD ≤  0.25% (2.0 to 4.9 μL)
RSD ≤  0.15% (more than 5.0 μL)
Cross-contamination ≤  0.0010 % (without rinse)
≤  0.0003 % (with rinse, typically)
(under specified conditions)
Dip rinsing outside the needle and injection port rinsing Included as standard
External needle flushing Included as standard
Internal needle flushing (3 solvents) Included as standard
Sample cooler Included as standard (air-circulation temperature control type)
Sample cooler temperature setting range 4 to 45 °C
(To set 4 °C, room temperature needs to be below 30 °C and humidity below 70 %)
Sample cooler temperature accuracy ±2 °C (sensor position ±0.5 °C)
Wetted materials Mobile phase flow line: SUS316L, DLC, PEEK
Other flow lines: SUS316L, PTFE, ETFE, FEP, GFP, sapphire, PPS, FEKM
Available pH range 1 to 14
Dimensions and weight W260 × D500 × H280 mm (protrusion adds 140 mm to the depth), 24 kg
Operating temperature range 4 to 35 °C
Power supply 100 to 240 V AC, 50/60 Hz, 400 VA

Plate Changer

  PLATE CHANGER
Plate Changer

 

 Number of samples processed
(including 2 plates of autosampler)		 Using 1 plate changer:
1536 (microtiter plate, 96 well × 16 plates)
864 (deep-well plate, 96 well × 9 plates)
6144 (microtiter plate, 384 well × 16 plates)
3456 (deep-well plate, 384 well × 9 plates)
756 (1 mL sample vial, 84 × 9 plates)
486 (1.5 mL sample vial, 54 × 9 plates)
252 (4 mL sample vial, 28 × 9 plates)
108 (10 mL sample vial, 12 × 9 plates)		 Using 3 plate changer:
4224 (microtiter plate, 96 well × 44 plates)
2208 (deep-well plate, 96 well × 23 plates)
16896 (microtiter plate, 384 well × 44 plates)
8832 (deep-well plate, 384 well × 23 plates)
1932 (1 mL sample vial, 84 × 23 plates)
1242 (1.5 mL sample vial, 54 × 23 plates)
644 (4 mL sample vial, 28 × 23 plates)
276 (10 mL sample vial, 12 × 23 plates)
Sample cooler Air-circulation temperature control type, 4 to 45 °C
(To set 4 °C, room temperature needs to be below 30 °C and humidity below 70 %)
Dimensions and weight W170 × D500 × H560 mm (protrusion adds 140 mm to the depth), 26 kg
Operating temperature
range		 4 to 35 °C
Dimensions and weight W260 × D500 × H72 mm, 5 kg
Operating temperature range 4 to 35 °C
Power supply (for 1 unit) 100 to 240 V AC, 400 VA, 50/60 Hz

Column Oven

    CTO-40C CTO-40S
Column Oven

 

 Temperature control type Forced air circulation
Cooling method Electronic cooling
Temperature control range Room temperature—10 to 100 °C Room temperature—10 to 85 °C
Temperature accuracy ±0.5 °C ±0.8 °C
Temperature precision 0.1 °C (±0.05 °C) 0.2 °C (±0.1 °C)
Containable column size and number 6 columns, each up to 250 mm long,
or 3 columns, each up to 300 mm long		 6 columns, each up to 100 mm long,
or 3 columns, each up to 300 mm long
Dimensions and weight W260 × D500 × H415 mm, 21 kg W130 × D500 × H553 mm, 15 kg
Operating temperature range 4 to 35°C
Power supply 100 to 120 V AC/220 to 240 V AC
(automatic switching)
400 VA, 50/60 Hz		 100 to 240 V AC, 300 VA, 50/60 Hz

 

PDA Detector

  SPD-M40 X4
PDA Detector

 

 Light source D2 lamp
Number of photodiode array elements 1024
Wavelength range 190 to 800 nm
Wavelength accuracy ≤  ±1 nm
Wavelength reproducibility ≤ ±0.1 nm
Slit width 1.2 nm, 8 nm
Spectral resolution ≤  1.4 nm
Drift ≤ 0.5 × 10-3 of AU/h (under specified conditions)
Noise ≤ 4.0 × 10-6 AU (under specified conditions)
Linearity 3.0 AU (under specified conditions, typically)
Flow cell Optical path length: 10 mm, Cell volume: 0.5 μL, Maximum pressure: 8 MPa
Material of wetted parts: PEEK, PCTFE, PFA, quartz
Sampling rate Max. 250 Hz
Optional flow cell High-sensitivity cell
(Optical path length: 85 mm, Cell volume: 4.2 μL, Maximum pressure: 8 MPa)
Available pH range 1 to 13 (Depending on the type of mobile phase, if used for a long period at pH 10 or higher,
the quartz of the flow cell may be damaged, causing changes in transmission properties.)
Dimensions and weight W260 × D500 × H140 mm, 10 kg
Operating temperature range 4 to 35 °C
Power supply 100 to 240 V AC, 180 VA, 50/60 Hz
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